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GET USE FOR UR EXAMS hope it might help you DIURETICS Type of diuretics Drug P rimar y Site of action Other sites effect on renal hemodynamics Excreted ions pH uses Adverse effects Carbonic anhydrase inhibition [ abolish NaHCO3 reabsorption in proximal tubule] Acetazolamide (DIAMOX), Dichlorphenamide (DARAMIDE), Methazolamide (GLAUCTABS). Proximal tubular epithelial cells Collecting ducts Increase delivery of solutes to the macula densa , increase afferent arteriolar resistance and reduces renal blood flow and GFR Increasing HCO3 –  & phosphate excretion Increase in urinary Ph –> metabolic acidosis Edema , treat epilepsy, relief in patients with high-altitude illness or mountain sickness , useful in pts with familial periodic paralysis, treatment of dural ectasia in individulas with marfansyndrome, of sleep apnea, and of idiopathic intracranial hypertension , correct metabolic alkalosis. Large doses exh...

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